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Warm-offering Inhibitors

ROCK inhibitor

Y-27632 dihydrochloride

Y-27632 dihydrochloride is really a picky ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, shows>200-fold selectivity over other kinases, including PKC, camping-dependent health proteins kinase, MLCK and PAK.

Connected Merchandise: Thiazovivin, Fasudil (HA-1077) HCl

GSK-3 inhibitor

CHIR-99021

CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, and that is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM power to separate GSK-3 as well as its closest homologs Cdc2 and ERK2.

Relevant Merchandise: SB216763 , CHIR-98014

Proteasome Inhibitor

MG-132

MG-132 is surely an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM.

Associated Merchandise: Carfilzomib (PR-171) , ONX-0914 (PR-957)

HDAC Inhibitor

Romidepsin (FK228, Depsipeptide)

Romidepsin (FK228, depsipeptide) is actually a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, correspondingly.

Related Merchandise: Entinostat (MS-275) , Trichostatin A (TSA)

Akt Inhibitor

MK-2206 2HCl

MK-2206 2HCl is a highly picky inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively no inhibitory activities against 250 other proteins kinases noticed. Cycle 2.

Associated Products: AZD5363 , GDC-0068

Raf Inhibitor

Vemurafenib

Vemurafenib (PLX4032, RG7204) is actually a innovative and potent inhibitor of B-RafV600E with IC50 of 31 nM.

Related Products: Sorafenib Tosylate , PLX-4720

Product or service Catalog

Compound Catalogue

32 forms of compound libraries for high throughput evaluating and content verification.

Research Areas

Proteases/Proteasome

Chromatin/Epigenetic

JAK/STAT Signaling

Tyrosine Kinase/Adaptors

PI3K/Akt/mTOR Signaling

MAPK Signaling

Apotosis

Ubiquitination

Angiogenesis

Immunology/Swelling

DNA Harm/DNA Fix

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