Little Substances, Key Jobs

Cyclopamine Chemical product DesignCyclopamine

Cyclopamine is truly a unique Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 cells.

Assessment spotlight: Connection with Cyclopamine encourages pancreatic enlargement in embryonic ladies. (Kim SK, et,al. PNAS, 1998, 95: 13036-13041.)

This product can be found in : Bioactive Component Local local library, Organic and natural Component Nearby local library

TWS119 Substance StructureTWS119

TWS119 is actually a GSK-3β inhibitor with IC50 of 30 nM inside the mobile phone-totally free assay able to inducing neuronal differentiation and may even be appropriate to originate mobile phone biology.

Assessment highlight: TWS119, a 4,6-disubstituted pyrrolopyrimidine that could cause neurogenesis in murine ESCs. (Ding S, et,al. PNAS, 2003,100(13): 7632-7637. )

The product is made up of in : Bioactive Compound Nearby local library

Nicotinamide Compound PlatformNicotinamide

Nicotinamide (Vitamin supplement B3), a normal water-soluble nutritional, is unquestionably an productive part of coenzymes NAD and NADP, and likewise serve as an activator of sirtuins.

Analysis highlight: Nicotinamide improved the produce of differentiation of Embryonic Come Cells to pancreatic endocrine tissues (Lumelsky N,et,al.Investigation, 2001, 292(5520): 1389-1394 )

The product contains in : Approved Drug Library, Regular Ingredient Series

Testing libraries to recognize much more functionally distinctive tiny substances!

Consists of 3071 small molecule substances

A distinctive number of 1700 authorized prescription drugs

Capabilities 640 all-normal ingredients

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