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Bet Bromodomain Inhibitor

(+)-JQ-1

(+)-JQ1 might be a Guess bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in portable-totally free assays, binding to any or all bromodomains of the Bet family members, yet not to bromodomains far from BET relatives.

Appropriate Items: GSK6853, CPI-637

GSK-3 Inhibitor

CHIR-99021

CHIR-99021 (CT99021) is in reality a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively.

Connected Merchandise: TDZD-8 , SB 216763

MEK Inhibitor

PD98059

PD98059 can be quite a non-ATP very competitive MEK inhibitor with IC50 of 2 μM within a cell phone-price-cost-free assay, specifically inhibits MEK-1-mediated activation of MAPK will not likely directly prevent ERK1 or ERK2.

Associated Goods: GDC-0623 , APS-2-79

AChR Antagonist

Forskolin

Forskolin is in reality a all-pervasive activator of eukaryotic adenylyl cyclase (AC) in numerous cell phone types, frequently used to enhance levels of outdoor camping in the overview and examine of cellphone physiology.

Relevant Merchandise: Isoprenaline hydrochloride

G9a/GLP Inhibitor

A-366

Highly effective and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50= 3.3 nM).

Connected Products: DIM-C-pPhOH , CCT241736

Product Catalog

Substance Collection

45 types of substance libraries for leading throughput testing and details verification.

Analysis Areas

Proteases/Proteasome

Chromatin/Epigenetic

JAK/STAT signaling

Tyrosine Kinase/Adaptors

PI3K/Akt/mTOR Signaling

MAPK Signaling

Apotosis

Ubiquitination

Angiogenesis

Immunology/Puffiness

DNA Harm/DNA Maintenance

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