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Well-known Ingredients in PI3K/Ark/mTOR inhibitor Series

PI3K

LY294002

CAS No. 154447-36-6

LY294002 could be the original synthetic molecule acknowledged to restrict PI3Kα/δ/β with IC50 of .5 μM/.57 μM/.97 μM in cellular-totally free assays, correspondingly much more stable in option than Wortmannin, and in addition obstructs autophagosome development.

Akt

Perifosine

CAS No. 157716-52-4

Perifosine (KRX-0401) is truly a unique Akt inhibitor with IC50 of 4.7 μM in Millimeters.1S tissues, focuses on pleckstrin homology web site of Akt. Time 3.

mTOR

Everolimus

CAS No. 159351-69-6

Everolimus (RAD001) is undoubtedly an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in the cell-charge-free of charge assay.

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